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Lookup NU author(s): Dr Scott Muller,
Dr Meng Khaw,
Professor Paul Gregg
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Ulceration of the lower leg is considered to be a 'hard' clinical endpoint of venous thrombosis. Total knee replacement (TKR) is a significant risk factor for venous thrombosis of the leg and therefore potentially for ulceration. We sent a postal questionnaire to 244 patients at a minimum of five years after TKR enquiring about the development of ulceration since their TKR. The overall incidence of ulceration, both active and healed, was 8.67% which is similar to that in the age-matched general population (9.6% to 12.6%), as was the prevalence of active ulceration. We also identified no clear association between venographically-confirmed postoperative deep-venous thrombosis (DVT) and the incidence and prevalence of ulcers at five years. We suggest that after TKR DVT is not a significant risk factor for ulceration of the leg and that perioperative chemical thromboprophylaxis may not be justified on these grounds.
Author(s): Muller SD; Khaw FM; Gregg PJ; Morris R; Crozier AE
Publication type: Article
Publication status: Published
Journal: Journal of Bone and Joint Surgery
ISSN (print): 0301-620X
ISSN (electronic): 2044-5377
Publisher: British Editorial Society of Bone and Joint Surgery
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