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Ulceration of the lower leg after total knee replacement - A five-year review

Lookup NU author(s): Dr Scott Muller, Dr Meng Khaw, Professor Paul Gregg


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Ulceration of the lower leg is considered to be a 'hard' clinical endpoint of venous thrombosis. Total knee replacement (TKR) is a significant risk factor for venous thrombosis of the leg and therefore potentially for ulceration. We sent a postal questionnaire to 244 patients at a minimum of five years after TKR enquiring about the development of ulceration since their TKR. The overall incidence of ulceration, both active and healed, was 8.67% which is similar to that in the age-matched general population (9.6% to 12.6%), as was the prevalence of active ulceration. We also identified no clear association between venographically-confirmed postoperative deep-venous thrombosis (DVT) and the incidence and prevalence of ulcers at five years. We suggest that after TKR DVT is not a significant risk factor for ulceration of the leg and that perioperative chemical thromboprophylaxis may not be justified on these grounds.

Publication metadata

Author(s): Muller SD; Khaw FM; Gregg PJ; Morris R; Crozier AE

Publication type: Article

Publication status: Published

Journal: Journal of Bone and Joint Surgery

Year: 2001

Volume: 83B

Issue: 8

Pages: 1116-1118

ISSN (print): 0301-620X

ISSN (electronic): 2044-5377

Publisher: British Editorial Society of Bone and Joint Surgery


DOI: 10.1302/0301-620X.83B8.11950


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