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Free radicals in alcoholic myopathy: Indices of damage and preventive studies

Lookup NU author(s): Dr David Mantle


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Chronic alcoholic myopathy affects up to two-thirds of all alcohol misusers and is characterized by selective atrophy of Type If (glycolytic, fast-twitch, anaerobic) fibers. In contrast, the Type I fibers (oxidative, slow-twitch, aerobic) are relatively protected. Alcohol increases the concentration of cholesterol hydroperoxides and malondialdehyde-protein adducts, though protein-carbonyl concentration levels do not appear to be overtly increased and may actually decrease in some studies. In alcoholics, plasma concentrations of a-tocopherol may be reduced in myopathic patients. However, a-tocopherol supplementation has failed to prevent either the loss of skeletal muscle protein or the reductions in protein synthesis in alcohol-dosed animals. The evidence for increased oxidative stress in alcohol-exposed skeletal muscle is thus inconsistent. Further work into the role of ROS in alcoholic myopathy is clearly warranted. (C) 2002 Elsevier Science Inc.

Publication metadata

Author(s): Preedy VR, Adachi J, Asano M, Koll M, Mantle D, Niemela O, Parkkila S, Paice AG, Peters T, Rajendram R, Seitz H, Ueno Y, Worrall S

Publication type: Review

Publication status: Published

Journal: Free Radical Biology & Medicine

Year: 2002

Volume: 32

Issue: 8

Pages: 683-687

ISSN (print): 0891-5849

ISSN (electronic): 1873-4596


DOI: 10.1016/S0891-5849(01)00794-8