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Lookup NU author(s): Emeritus Professor Doug Turnbull,
Professor Patrick Chinnery
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Very low levels of somatic mitochondrial (mt)DNA deletions have been identified in the semen of infertile men. It has been suggested that these mutations cause infertility through an effect on sperm motility, but there has been no direct evidence to show that mutant mtDNA can affect sperm function. We have carried out semen analysis on a male harbouring the A3243G mtDNA mutation and show that high levels of mutant mtDNA strongly correlate with low sperm motility.
Author(s): Chinnery PF; Turnbull DM; Spiropoulos J
Publication type: Article
Publication status: Published
Journal: Molecular Human Reproduction
ISSN (print): 1360-9947
ISSN (electronic): 1460-2407
Publisher: Oxford University Press
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