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Can mitochondrial DNA mutations cause sperm dysfunction?

Lookup NU author(s): Emeritus Professor Doug Turnbull, Professor Patrick Chinnery

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Abstract

Very low levels of somatic mitochondrial (mt)DNA deletions have been identified in the semen of infertile men. It has been suggested that these mutations cause infertility through an effect on sperm motility, but there has been no direct evidence to show that mutant mtDNA can affect sperm function. We have carried out semen analysis on a male harbouring the A3243G mtDNA mutation and show that high levels of mutant mtDNA strongly correlate with low sperm motility.

Publication metadata

Author(s): Chinnery PF; Turnbull DM; Spiropoulos J

Publication type: Article

Publication status: Published

Journal: Molecular Human Reproduction

Year: 2002

Volume: 8

Issue: 8

Pages: 719-721

ISSN (print): 1360-9947

ISSN (electronic): 1460-2407

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/molehr/8.8.719

DOI: 10.1093/molehr/8.8.719

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