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Conditionally immortalized cell lines as model systems for high-throughput biology in drug discovery

Lookup NU author(s): Dr Reza Halse, Emeritus Professor Steve Yeaman


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There is an increasing emphasis on the need for high-quality biological data much earlier in the drug-discovery process. This has led to the development of high-throughput approaches to biology, many of which rely on the use of cell-culture models. Unfortunately, available cell-culture models often reflect poorly the characteristics of the tissue they are supposed to represent. However, the conditional-immortalization approach as applied by Xcellsyz offers the possibility of producing human cell lines on demand, which are truly representative of the tissue from which they derive.

Publication metadata

Author(s): Daniele N, Halse R, Grinyo E, Yeaman SJ, Shepherd PR

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Transactions: Meeting on High-Throughput Screening - The Way Ahead

Year of Conference: 2002

Pages: 800-802

ISSN: 0300-5127

Publisher: Portland Press Ltd.

Library holdings: Search Newcastle University Library for this item

Series Editor(s):

ISBN: 14708752