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Rapid intravenous administration of granisetron prior to chemotherapy is not arythmogenic: results of a pilot study

Lookup NU author(s): Dr John Bourke


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Patients with advanced malignancy are at an increased risk of cardiac arrhythmias, from their cancer and cardiotoxic treatments. Supportive care products co-administered should therefore not increase this risk. No clinically important cardiovascular effects are associated with the administration of granisetron over 30 s. To determine the effects of a rapid (I s) injection of granisetron, 3 mg, on measures of cardiac repolarisation, a pilot study was performed in 17 patients undergoing moderately/highly emetogenic chemotherapy at two centres. All received dexamethasone, 8-12 mg, infused over 30 min, followed immediately by granisetron and then chemotherapy. Twelve-lead electrocardiograms (ECGs) performed before granisetron treatment, 2 h later and the following day (I I patients) showed no differences in QTc(end max), QTc(apex max) or QT-interval dispersion between baseline and subsequent measurements, and there were no significant secondary adverse events. On this basis, granisetron should be considered the first-choice antiemetic for patients at increased risk of cardiac complications. (C) 2003 Published by Elsevier Science Ltd.

Publication metadata

Author(s): Aapro M, Bourke JP

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 2003

Volume: 39

Issue: 7

Pages: 927-931

ISSN (print): 0959-8049

Publisher: Pergamon


DOI: 10.1016/S0959-8049(03)00120-5


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