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Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke

Lookup NU author(s): Dr Emma Burton, Dr Clive Ballard, Professor Rose Anne Kenny, Professor Raj KalariaORCiD, Dr Robert Barber, Professor John O'Brien


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Aim: The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits. Method. Detailed neuropsychological assessments (attention and working memory) were undertaken in 50 stroke survivors >75 years of age [38 with ageing-associated cognitive decline (AACD)] and 15 age-matched controls. A 1.5-tesla General Electric MRI scanner was used. Standardized visual ratings were undertaken of white matter hyperintensities (WMH). Grey matter volumes were assessed using voxel-based morphometery. Results: Associations were identified between processing speed and executive function and the severity of WMH in key areas. In addition, atrophy in the fronto-subcortical circuits was associated with AACD. Conclusion: Attentional and executive impairments are underpinned by WMH in fronto-striato-thalamo-frontal circuits. Frontal atrophy is identified as a novel substrate of cognitive decline in stroke patients. Copyright (C) 2003 S. Karger AG, Basel.

Publication metadata

Author(s): Burton E, Ballard C, Stephens S, Kenny RA, Kalaria R, Barber R, O'Brien J

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2003

Volume: 16

Issue: 2

Pages: 113-118

Print publication date: 01/01/2003

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG


DOI: 10.1159/000070684

PubMed id: 12784036


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