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Radiological features predictive of aseptic loosening in cemented Charnley femoral stems

Lookup NU author(s): Dr Iain Chambers, Professor Andrew McCaskie, Professor Paul Gregg


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The radiological features of the cement mantle around total hip replacements (THRs) have been used to assess aseptic loosening. In this case-control study we investigated the risk of failure of THR as predictable by a range of such features using data from patients recruited to the Trent Regional Arthroplasty Study (TRAS). An independent radiological assessment was undertaken on Charnley THRs with aseptic loosening within five years of surgery and on a control group from the TRAS database. Chi-squared tests were used to test the probability of obtaining the observed data by chance, and odds ratios were calculated to estimate the strength of association for different features. Several features were associated with a clinically important increase (> twofold) in the risk of loosening, which was statistically significant for four features (p < 0.01). Inadequate cementation (Barrack C and D grades) was the most significant feature, with an estimated odds ratio of 9.5 (95% confidence interval 3.2 to 28.4, p < 0.0001) for failure.

Publication metadata

Author(s): Gregg PJ; McCaskie AW; Chambers IR; Fender D; Reeves BC

Publication type: Article

Publication status: Published

Journal: Journal of Bone and Joint Surgery (British Volume)

Year: 2001

Volume: 83

Issue: 6

Pages: 838-842

ISSN (print): 0301-620X

ISSN (electronic): 2044-5377

Publisher: British Editorial Society of Bone and Joint Surgery


DOI: 10.1302/0301-620X.83B6.11659


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