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Reflux of gastric juice and glue ear in children

Lookup NU author(s): Dr Andrea Tasker, Professor Jeffrey Pearson


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Otitis media with effusion (glue ear) is the most frequent cause of deafness in children. We investigated the role of gastric juice reflux in this disease. We measured pepsin concentrations in middle ear effusions from children using ELISA and enzyme activity assays. 45 (83%) of 54 effusions contained pepsin/pepsinogen at concentrations of up to 1000-fold greater than those in serum. Our data suggest that reflux of gastric juice could be a major cause of glue ear in children.

Publication metadata

Author(s): Pearson JP; Tasker A; Dettmar PW; Panetti M; Koufman JA; Birchall JP

Publication type: Article

Publication status: Published

Journal: Lancet

Year: 2002

Volume: 359

Issue: 9305

Pages: 493

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group


DOI: 10.1016/S0140-6736(02)07665-1


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