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Lookup NU author(s): Dr Diana Mansour
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Objective: To assess the adhesive reliability of the contraceptive patch (Ortho Evra(TM)/Evra(TM)), Design: Pooled data of 3,319 women from three contraceptive studies of up to 13 treatment cycles; a subset of 325 women of the pooled data from warm and humid climates; and 30 women from a three-period, crossover exercise study. Setting: 184 centers. Patient(s): 3,349 healthy women. Intervention(s): In the contraceptive studies, each treatment cycle consisted of three consecutive 7-day patches (21 days) followed by one patch-free week. During each treatment period in the exercise study, women wore the patch for 7 days and participated in one of six activities (normal activity, excluding bathing; sauna; whirlpool; treadmill; cool-water immersion; or a combination of activities) each day at a supervised health center. Main Outcome Measure(s): Patch adhesion. Result(s): In the contraceptive studies, 4.7% of patches were replaced because they fell off (1.8% [1,297 of 70,552 patches]) or became partly detached (2.9% [2,050 of 70,552 patches]); patch replacement rates in centers from a warm, humid climate were 1.7% (85 of 4,877 patches) and 2.6% (128 of 4,877 patches), respectively. Only one of 87 patches (1.1%) completely detached in the exercise study. Conclusion(s): The reliability of adhesion of the contraceptive patch is excellent and consistent across all studies; only 1.8% and 2.9% of patches required replacement due to complete or partial detachment, respectively. Heat, humidity, and exercise do not affect adhesion.
Author(s): Zacur HA, Hedon B, Mansour D, Shangold GA, Fisher AC, Creasy GW
Publication type: Article
Publication status: Published
Journal: Fertility and Sterility
Year: 2002
Volume: 77
Issue: 2
Pages: S32-S35
ISSN (print): 0015-0282
ISSN (electronic): 1556-5653
Publisher: Elsevier Inc.
URL: http://dx.doi.org/10.1016/S0015-0282(01)03262-9
DOI: 10.1016/S0015-0282(01)03262-9
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