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Lookup NU author(s): Dr Robert Barber,
Professor Ian McKeith,
Dr Clive Ballard,
Professor John O'Brien
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Objectives: To determine whether parkinsonian symptoms dementia with Lewy bodies (DLB) are associated with greater atrophy of the caudate nucleus in comparison with patients with Alzheimer's disease (AD) and vascular (VaD). Methods: T1 weighted MR scans were acquired in elderly patients With DLB, AD, VaD, and healthy controls. Normalised volumetric measurements of the caudate nucleus were obtained and parkinsonian symptoms rated using Hoehn and Yahr staging. Results: There were no significant differences in the volume of the caudate nucleus between patients with : dementia. However, the left caudate volume was significantly reduced in AD and DLB compared with controls. Parkinsonian symptoms did not correlate with caudate nucleus volume. Conclusions: Parkinsonian symptoms in DLB may be more closely coupled to neurochemical rather than structural changes in the caudate nucleus, and volumetric MRI analysis of caudate nucleus does not discriminate between patients with DLB, AD, and VaD.
Author(s): Barber R, McKeith I, Ballard C, O'Brien J
Publication type: Article
Publication status: Published
Journal: Journal of Neurology, Neurosurgery and Psychiatry
ISSN (print): 0022-3050
ISSN (electronic): 1468-330X
Publisher: BMJ Group
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