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Effects of dental local anaesthetics in cardiac transplant recipients

Lookup NU author(s): Dr John Meechan, Professor Mark Thomason


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Objective To investigate the cardiovascular responses of cardiac transplant recipients to dental local anaesthetic solutions with and without epinephrine (adrenaline). Materials and methods A clinical study employing 30 patients (20 cardiac transplant recipients and ten healthy) awaiting gingival or minor oral surgery under local anaesthesia receiving either 4.4 ml lidocaine (lignocaine) with 1:80,000 epinephrine or 4.4 ml 3% prilocaine with 0.03lU/ml felypressin. Results Cardiac transplant patients experienced a significant tachycardia 10 minutes after injection of the epinephrine-containing solution. No significant change in heart rate was detected after the injection of an epinephrine-free solution. Blood pressure was not affected. Periodontal surgery did not affect the responses to the local anaesthetics in the transplant recipients. Conclusions The cardiovascular response to dental local anaesthesia in cardiac transplant recipients is governed by the solution injected.

Publication metadata

Author(s): Thomason JM; Meechan JG; Parry G; Rattray DT

Publication type: Article

Publication status: Published

Journal: British Dental Journal

Year: 2002

Volume: 192

Issue: 3

Pages: 161-163

ISSN (print): 0007-0610

ISSN (electronic): 1476-5373

Publisher: Nature Publishing Group


DOI: 10.1038/sj.bdj.4801323


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