Toggle Main Menu Toggle Search

Open Access padlockePrints

Role of aminoglycosides in the treatment of bacterial endocarditis

Lookup NU author(s): Professor Kate Gould


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Aminoglycosides are often used in combination with glycopeptides and beta-lactams for the treatment of bacterial endocarditis caused by alpha-haemolytic streptococci, staphylococci and enterococci. Recommendations on dosing and duration of aminoglycoside therapy vary; we detail the laboratory and clinical evidence base for the treatment regimens advised. A number of deficiencies in the published guidelines are highlighted, as is the limited evidence base upon which many of the regimens are recommended. With the increasing use of outpatient treatment of severe infections and once daily administration of aminoglycosides the opportunity should be taken for larger, multicentre clinical trials to evaluate formally both old and new regimens.

Publication metadata

Author(s): Graham JC, Gould FK

Publication type: Review

Publication status: Published

Journal: Journal of Antimicrobial Chemotherapy

Year: 2002

Volume: 49

Issue: 3

Pages: 437-443

ISSN (print): 0305-7453

ISSN (electronic): 1460-2091


DOI: 10.1093/jac/49.3.437