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Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension

Lookup NU author(s): Dr Michael Thompson, Dr Trevor Thomas, Professor Albert Geerts

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Abstract

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary machinery to contract or relax in response to a number of vasoactive substances. Because stellate cells play a role in both fibrosis and portal hypertension, they are currently regarded as therapeutic targets to prevent and treat the complications of chronic liver disease.

Publication metadata

Author(s): Geerts A; Thompson MG; Thomas T; Reynaert H

Publication type: Review

Publication status: Published

Journal: Gut

Year: 2002

Volume: 50

Issue: 4

Pages: 571-581

ISSN (print): 0017-5749

ISSN (electronic): 1468-3288

URL: http://dx.doi.org/10.1136/gut.50.4.571

DOI: 10.1136/gut.50.4.571

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