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Lookup NU author(s): Professor Roy Taylor, Emerita Professor Sally Marshall, Emeritus Professor John Davison
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OBJECTIVE: To evaluate predictors of neonatal hypoglycemia and macrosomia in 107 consecutive pregnancies in type 1 diabetic women. METHODS: We conducted a case record analysis of singleton type 1 diabetic pregnancies between January 1994 and January 1999 following institution of standardized management. RESULTS: The duration of diabetes in the women was 12.9 +/- 6.8 years, and 44 were primigravidas. The mean HbA1c throughout pregnancy was 7.2 +/- 0.8%. There was no relationship between neonatal blood glucose (checked before the second feed) and HbA1c at any point in pregnancy or mean pregnancy HbA1c (R = 0.20, P > .1). However, there was a negative correlation between neonatal blood glucose and maternal blood glucose during labor (R = -0.33, P < .001). When maternal blood glucose during labor was greater than 8 mM (144 mg/dL), neonatal blood glucose was usually less than 2.5 mM (mean 1.7 +/- 0.4 mM or 31 mg/dL). There was no relationship between mean HbA1c and birth weight (R = 0.02, P > .1) or between maximum insulin dose and birth weight (R = 0.09, P > .1). Fetal abdominal circumference measured by ultrasound at 34 weeks correlated strongly with birth weight (R = 0.72, P < .001). CONCLUSION: Neonatal hypoglycemia correlates with maternal hyperglycemia in labor, not with HbA1c during pregnancy. Macrosomia does not correlate with HbA1c during pregnancy. (C) 2002 by the American College of Obstetricians and Gynecologists.
Author(s): Taylor R, Lee C, Kyne-Grzebalski D, Marshall SM, Davison JM
Publication type: Article
Publication status: Published
Journal: Obstetrics and Gynecology
Year: 2002
Volume: 99
Issue: 4
Pages: 537-541
ISSN (print): 0029-7844
ISSN (electronic): 1873-233X
Publisher: Lippincott Williams & Wilkins
URL: http://dx.doi.org/10.1016/S0029-7844(01)01790-2
DOI: 10.1016/S0029-7844(01)01790-2
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