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Lookup NU author(s): Dr Mario Abinun, Professor Andrew Cant
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Human primary immunodeficiency diseases are experiments of nature characterized by an Increased susceptibility to Infection. In many cases, they are also associated with troublesome and sometimes life-threatening autolmmune complications. In the past few years, great strides have been made In understanding the molecular basis of primary immunodeficiencies, and this had led to more focused and successful treatment. This review has 3 aims: (1) to highlight the variety of autoimmune phenomena associated with human primary immunodeficiency diseases; (2) to explore how primary immunodeficiencies predispose patients to autolmmune phenomena triggered by opportunistic infections; and (3) to consider the rationale for the current treatment strategies for autoimmune phenomena, specifically in relation to primary immunodeficiency diseases. Reviewing recent advances In our understanding of the small subgroup of patients with defined causes for their autoimmunity may lead to the development of more effective treatment strategies for Idiopathic human autolmmune diseases. (C) 2002 by The American Society of Hematology.
Author(s): Abinun M; Cant AJ; Arkwright PD
Publication type: Review
Publication status: Published
Journal: Blood
Year: 2002
Volume: 99
Issue: 8
Pages: 2694-2702
ISSN (print): 0006-4971
ISSN (electronic): 1528-0020
URL: http://dx.doi.org/10.1182/blood.V99.8.2694
DOI: 10.1182/blood.V99.8.2694
