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A population-based study of intensive multi-agent chemotherapy with or without autotransplant for the highest risk Hodgkin's disease patients identified by the Scotland and Newcastle Lymphoma Group (SNLG) prognostic index. A Scotland and Newcastle Lymphoma Group study (SNLG HD III)

Lookup NU author(s): Professor Stephen Proctor, Dr Brian Angus, Professor Graham Jackson, Dr Anne Lennard, Dr Penelope Taylor


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The aim of the study was to identify all patients with poor risk Hodgkin's disease (HD) using a numerical prognostic index in a defined population and to recruit them into a trial of intensive chemotherapy prednisolone, vinblastine, doxorubicin, chlorambucil, etoposide, bleomycin, vincristine, procarbazine (PVACE-BOP) x 3 + autotransplant (Arm A) versus PVACE-BOP x 5 (Arm B) in first remission. In 10 years, the Scotland and Newcastle Lymphoma Group (SNLG) registered 930 patients with HD of whom 178 (19%) were identified as 'poor risk' by the SNLG index and were aged 16-59 years. 126/178 (71%) entered the study. Of the 120 confirmed poor risk HD cases, all completed PVACE-BOPx3 with a 93% Complete Response/unconfirmed Complete Response (CR/CRu) rate. Only 65/107 in CR accepted the randomisation. With a median follow-up of 6 years, both arms of the trial have a similar time to treatment failure (TTF) (Arm A 79% +/- 11 versus 85% +/- 7 Arm B, P=0.35). Advanced stage 'good risk' patients not included in the trial receiving standard therapy with CLVPP or ABVD had a 75% 5-year survival. The study demonstrates that PVACE-BOP therapy in the poorest risk group (58% had an IPI greater than or equal to 3) produces excellent CR rates (93%) and overall survival with minimal toxicity, and that the substitution of autotransplant in first CR does not improve outcome. The use of the objective SNLG index accurately helped in the selection of the poorest risk group in this population Study. The placing of a randomised control trial within the context of a population-based study of 11 D enhances the validity of the outcome. (C) 2002 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Proctor SJ, Mackie M, Dawson A, White J, Prescott RJ, Lucraft HL, Angus B, Jackson GH, Lennard AL, Heppletone A, Taylor PRA

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 2002

Volume: 38

Issue: 6

Pages: 795-806

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852


DOI: 10.1016/S0959-8049(02)00006-0


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