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Epithelial cell proliferative activity and oral cancer progression

Lookup NU author(s): Professor Peter Thomson


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Accurate, predictive assessment of the behaviour and progression of oral cancers and precancers remains elusive in clinical practice. Archival tissue specimens from 10 previously treated patients with oral lesions of known clinical outcome (3 years post-treatment) were re-examined histopathologically, and proliferative cell labelling indices (LIs) determined for Ki67, cyclin A and histone mRNA cell cycle markers. While histone mRNA labelling ultimately proved unreliable, both Ki67 and cyclin A LIs demonstrated a clear trend for enhanced labelling to occur in increasingly dysplastic and neoplastic tissue, with particular emphasis on suprabasal labelling in abnormal tissue. Perhaps of greatest significance was the observation of increased LIs and suprabasal labelling in lesions with poor clinical outcome, such as patients developing recurrent disease or cervical lymph node metastasis. Measurement of cell proliferative activity in individual oral epithelial dysplastic lesions or invasive squamous cell carcinomas may thus provide unique, predictive information on clinical outcome.

Publication metadata

Author(s): Thomson PJ; Soames JV; Booth C; O'Shea JA

Publication type: Article

Publication status: Published

Journal: Cell Proliferation

Year: 2002

Volume: 35

Issue: s1

Pages: 110-120

ISSN (print): 0960-7722

ISSN (electronic): 1365-2184

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1046/j.1365-2184.35.s1.12.x


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