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Gender effects and Synergisms with histocompatibility leukocyte antigens in type 1 autoimmune hepatitis

Lookup NU author(s): Dr Peter Donaldson


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OBJECTIVES: Our goals were to determine the effect of gender on the clinical features and treatment outcome of type 1 autoimmune hepatitis, and to assess synergisms with the known genetic risk factors. METHODS: Clinical findings and treatment outcomes were compared in 144 women and 41 men who were also assessed for HLA DR3, HLA DR4, HLA DR3 and DR4 alleles, and the DRB1*1501-DQA1*102 haplotype by polymerase chain reaction. A total of 102 healthy men and women were similarly typed. RESULTS: Women were distinguished from men by higher frequencies of concurrent immune diseases (34% vs 17%, p = 0.05) and HLA DR4 (49% vs 24%, p = 0.007), as had been previously reported. Women, however, had a higher occurrence of non-DRB1*0401 DR4 alleles than men (15% vs 0%, p = 0.02), and men had a lower frequency of these alleles than did normal male subjects (0% vs 16%, p = 0.04). Men and women responded similarly to therapy. Treatment failure occurred more frequently in men only if they had HLA DR3 and women had HLA DR4 (25% vs 4%, p = 0.01). The DRB1*1501-DQA1*102 haplotype did not affect outcome. CONCLUSIONS: Gender influences susceptibility and clinical manifestations, but not outcome. Women have HLA DR4 more commonly than men, but this difference relates to their higher frequency of non-DRBI*0401 DR4 alleles. Female gender may promote risk associated with different HLA DR4 alleles.

Publication metadata

Author(s): Donaldson PT; Czaja AJ

Publication type: Article

Publication status: Published

Journal: American Journal of Gastroenterology

Year: 2002

Volume: 97

Issue: 8

Pages: 2051-2057

ISSN (print): 0002-9270

ISSN (electronic): 1572-0241

Publisher: Nature Publishing Group


DOI: 10.1111/j.1572-0241.2002.05921.x


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