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Lookup NU author(s): Marina Smirnova,
Professor Jeffrey Pearson
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Inflammation in the middle ear mucosa, caused usually by bacterial and viral pathogens, is the primary event in the middle ear predisposing the development of otitis media with effusion (OME). Numerous inflammatory mediators have been identified in OME. However, cytokines play a central role as initiators, mediators and regulators of middle ear inflammation and subsequent molecular-pathological processes in middle ear tissues, leading to histopathological changes in the middle ear cavity and the pathogenesis of OME. In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion.
Author(s): Smirnova MG, Kiselev SL, Gnuchev NV, Birchall JP, Pearson JP
Publication type: Review
Publication status: Published
Journal: European Cytokine Network
ISSN (print): 1148-5493
ISSN (electronic): 1952-4005