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Lookup NU author(s): Professor Andrew GenneryORCiD,
Professor Andrew Cant
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The authors describe two pediatric cases of large granular lymphocytosis presenting early in the second decade of life with neutropenia and sepsis. They are among the youngest described in the literature. This report focuses on the advantages of detailed immunophenotypic and molecular analysis and highlights some of the controversies and uncertainties in the management of these patients, particularly the choice of immunosuppressive therapy. Immunosuppressive therapy in the two children described in this report resulted in improvement of neutropenia and clinical status, but this was not accompanied by the disappearance of the clonal population.
Author(s): Krishna MT, Hodges E, Lavender FL, Harris S, Gennery A, Cant A, Gibson B, Wilkie R, Darbyshire P, Smith JL
Publication type: Article
Publication status: Published
Journal: Journal of Pediatric Hematology / Oncology
ISSN (print): 1077-4114
ISSN (electronic): 1536-3678
Publisher: Lippincott Williams & Wilkins
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