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CD3+CD4-CD8+NK- large granular lymphocytosis with neutropenia and evidence for clonality and T-Cell receptor gene rearrangement: Two pediatric cases

Lookup NU author(s): Professor Andrew GenneryORCiD, Professor Andrew Cant


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The authors describe two pediatric cases of large granular lymphocytosis presenting early in the second decade of life with neutropenia and sepsis. They are among the youngest described in the literature. This report focuses on the advantages of detailed immunophenotypic and molecular analysis and highlights some of the controversies and uncertainties in the management of these patients, particularly the choice of immunosuppressive therapy. Immunosuppressive therapy in the two children described in this report resulted in improvement of neutropenia and clinical status, but this was not accompanied by the disappearance of the clonal population.

Publication metadata

Author(s): Krishna MT, Hodges E, Lavender FL, Harris S, Gennery A, Cant A, Gibson B, Wilkie R, Darbyshire P, Smith JL

Publication type: Article

Publication status: Published

Journal: Journal of Pediatric Hematology / Oncology

Year: 2002

Volume: 24

Issue: 6

Pages: 495-498

ISSN (print): 1077-4114

ISSN (electronic): 1536-3678

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/00043426-200208000-00018


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