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Lookup NU author(s): Dr Jonathan Wallis
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Alloimmune neutropenia in neonates is rare. We describe severe and persistent neutropenia in a 4-week-old neonate, which arose within 2 h of a transfusion of blood that contained about 28 mL of plasma and in which strong antibodies against human neutrophil antigen 1b (HNA-1b) were subsequently identified. The infant was positive for HNA-1b. No other likely cause of neutropenia was discovered. We believe this complication of blood transfusion to be a previously unrecognised one, and have called the condition transfusion-related alloimmune neutropenia (TRAIN).
Author(s): Wallis JP, Haynes S, Stark G, Green FA, Lucas GF, Chapman CE
Publication type: Article
Publication status: Published
Journal: Lancet
Year: 2002
Volume: 360
Issue: 9339
Pages: 1073-1074
ISSN (print): 0140-6736
ISSN (electronic): 1474-547X
Publisher: The Lancet Publishing Group
URL: http://dx.doi.org/10.1016/S0140-6736(02)11132-9
DOI: 10.1016/S0140-6736(02)11132-9
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