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Lookup NU author(s): Dr Peter Donaldson
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Background/Aims: Though there is a consensus that the HLA DQB1 *0301 allele is important in untreated HCV clearance, this association is not universal and a number of genes outside the major histocompatibility complex may also play a role in host responses to HCV infection. Prime candidates, at present, are the genes encoding pro-inflammatory and immuno-regulatory cytokines. The aim of this study was to investigate the relationship between a number of these candidate genes and both spontaneous and treatment related clearance of hepatitis C virus infection. Methods: Three members of the interleukin-1 gene family: IL-1A , IL-1B and IL-1RN , three polymorphic sites in the interleukin-10 gene promoter (- 1082, - 819, - 592) and two in the tumour necrosis factor-alpha promoter (- 308, - 238) were studied in two independent DNA banks, each with appropriate controls. Standard PCR-based genotyping techniques were used. Results: No significant difference in the distribution of any of the polymorphisms was found in either study set. Conclusions: These findings in two large groups suggest that future investigations should focus on other candidate genes and may support the view that MHC-encoded susceptibility to chronic HCV infection may be determined by MHC class II rather than MHC class III genes.
Author(s): Constantini PK, Wawrzynowicz-Syczewska M, Clare M, Boron-Kaczmarska A, McFarlane IG, Cramp ME, Donaldson PT
Publication type: Article
Publication status: Published
ISSN (print): 1478-3223
ISSN (electronic): 1478-3231
Publisher: Wiley-Blackwell Publishing, Inc.
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