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Acute rhabdomyolysis after cardiac transplantation: a diagnostic conundrum

Lookup NU author(s): Dr Jon Smith

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Abstract

A 13-year-old girl presented with right ventricular failure secondary to Ebstein's malformation (downward displacement of the tricuspid valve leaflets with adherence to the right ventricular muscle and redundancy or dysplasia of the tricuspid valve leaflets). She subsequently required a heart transplant but developed rhabdomyolysis early in the postoperative period and required ventilatory support for more than 3 weeks. A variety of causes were considered, but her condition improved only when cyclosporin was eliminated from the immunosuppression regimen. We believe it is likely that the rhabdomyolysis has been caused by cyclosporin. If so, this has occurred both earlier in the clinical course and at lower serum concentrations than previously described.

Publication metadata

Author(s): Cassidy JV, Bolton DT, Haynes SR, Smith JH

Publication type: Article

Publication status: Published

Journal: Paediatric Anaesthesia

Year: 2002

Volume: 12

Issue: 8

Pages: 729-732

ISSN (print): 1155-5645

ISSN (electronic): 1460-9592

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1046/j.1460-9592.2002.00936.x

DOI: 10.1046/j.1460-9592.2002.00936.x

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