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In vitro autoreactivity against skin and synovial cells in patients with juvenile idiopathic and rheumatoid arthritis

Lookup NU author(s): Professor Anne Dickinson


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In the present study we compared specific lysis of various autologous target cells in patients with juvenile idiopathic arthritis JIA; n = 8) or rheumatoid arthritis RA; n = 17) with those of healthy controls (n = 15). Cr-51-release cytotoxic assay with autologous peripheral blood mononuclear cells as effector cells was used. When compared with controls, effector cells of patients with JIA or RA were found to lyse significantly autologous synovial cells (p < 0.0005) and epidermal keratinocytes (p < 0.0005), however, no difference was found for autologous dermal fibroblasts. Copyright (C) 2002 S. Karger AG, Basel.

Publication metadata

Author(s): Stechova K, Vavrincova P, Chudoba D, Frantlova M, Reitzova H, Sosna A, Zimak J, Lednicky L, Dickinson AM, Hromadnikova I

Publication type: Article

Publication status: Published

Journal: Pathobiology

Year: 2002

Volume: 70

Issue: 2

Pages: 76-82

Print publication date: 01/01/2002

ISSN (print): 1015-2008

ISSN (electronic): 1423-0291

Publisher: S. Karger AG


DOI: 10.1159/000067306


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