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Drugs in development: bisphosphonates and metalloproteinase inhibitors

Lookup NU author(s): Dr Jonathan Catterall, Emeritus Professor Tim Cawston


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The destruction of bone and cartilage is characteristic of the progression of musculoskeletal diseases. The present review discusses the developments made with two different classes of drugs, the bisphosphonates and matrix metalloproteinase inhibitors. Bisphosphonates have proven to be an effective and safe treatment for the prevention of bone loss, especially in osteoporotic disease, and may have a role in the treatment of arthritic diseases. The development of matrix metalloproteinase inhibitors and their role as potential therapies are also discussed, especially in the light of the disappointing human trials data so far published.

Publication metadata

Author(s): Catterall JB, Cawston TE

Publication type: Review

Publication status: Published

Journal: Arthritis Research & Therapy

Year: 2003

Volume: 5

Issue: 1

Pages: 12-24

ISSN (print): 1478-6354

ISSN (electronic): 1478-6362


DOI: 10.1186/ar604