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Strategic approach to the management of Hodgkin's disease incorporating salvage therapy with high-dose ifosfamide, etoposide and epirubicin: a Northern Region Lymphoma Group study (UK)

Lookup NU author(s): Professor Stephen Proctor, Professor Graham Jackson, Dr Anne Lennard, Dr Brian Angus, Dr Katrina Wood, Dr Helen Lucraft, Dr Kevin Windebank, Dr Penelope Taylor


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The Northern Region Lymphoma Group is a population-based group covering 3.1 million people in Northern England. From 1991 total data collection for all Hodgkin's disease patients for this population has been in place and it has been possible to demonstrate that the overall survival for Hodgkin's disease for younger patients within this population has moved from 80% pre-1988 to 87% post-1988. This improvement has been brought about by the introduction of clinical trials for advanced stage disease and effective salvage regimens. This report describes the outcome of 51 patients treated with the ifosfamide, etoposide and epirubicin (IVE) schedule and includes 28 males and 23 females with a median age of 34 years. Overall 43 of 51 patients responded to treatment (84%) with 31 achieving a complete response, four a good partial response and eight a partial response. Thirty-one proceeded to autologous stem-cell transplantation. In total, with a median follow-up of 24 months (range 6-51), 26 patients remain alive and in continuous remission. Haematological toxicity, in particular neutropenia WHO grade 4, was observed in all cases but improved over the three courses of treatment. Non-haematological toxicity was not a major problem, with no significant cardiac, hepatic, renal or neurotoxicity. We conclude that the high-dose ifosfamide-containing regimens should be prospectively evaluated in the various types of non-responsive and relapsing Hodgkin's disease.

Publication metadata

Author(s): Proctor SJ, Jackson GH, Lennard AL, Angus B, Wood K, Lucraft HH, White J, Windebank K, Taylor PRA

Publication type: Article

Publication status: Unknown

Journal: Annals of Oncology

Year: 2003

Volume: 14

Issue: Supplement 1

Pages: 47-50

Print publication date: 01/01/2003

ISSN (print):

ISSN (electronic):


DOI: 10.1093/annonc/mdg710


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