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Low-grade malignant eccrine spiradenoma with systemic metastases

Lookup NU author(s): Dr Niamh Leonard, Dianne Smith, Dr Paul McNamara


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Malignant eccrine spiradenoma (MES) is a very rare tumor. Tumors can be low grade or high grade. There are nine cases in the literature with systemic metastases. Of these, only one was low grade; the others had obvious features of high-grade malignancy such as pleomorphism, increased mitoses, and abnormal mitoses. Low grade MESs are more difficult to diagnose and are said to have a better prognosis. We report an additional case of low-grade MES with systemic metastases. It had a monotonous appearance with few mitotic figures and minimal pleomorphism. Vascular invasion was seen in both cases of low-grade MES and may be an important prognostic feature.

Publication metadata

Author(s): Leonard N, Smith D, McNamara P

Publication type: Article

Publication status: Published

Journal: American Journal of Dermatopathology

Year: 2003

Volume: 25

Issue: 3

Pages: 253-255

ISSN (print): 0193-1091

ISSN (electronic): 1533-0311

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/00000372-200306000-00011


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