Toggle Main Menu Toggle Search

Open Access padlockePrints

Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs

Lookup NU author(s): Emeritus Professor Elaine Perry, Professor David Burn, Emeritus Professor Robert Perry


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.

Publication metadata

Author(s): Perry RH; Perry EK; Burn DJ; Kilford L; Lees AJ

Publication type: Article

Publication status: Published

Journal: Annals of Neurology

Year: 2003

Volume: 54

Issue: 2

Pages: 235-238

ISSN (print): 0364-5134

ISSN (electronic): 1531-8249

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/ana.10639


Altmetrics provided by Altmetric