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Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs

Lookup NU author(s): Emeritus Professor Elaine Perry, Professor David BurnORCiD, Emeritus Professor Robert Perry

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Abstract

The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.

Publication metadata

Author(s): Perry RH; Perry EK; Burn DJ; Kilford L; Lees AJ

Publication type: Article

Publication status: Published

Journal: Annals of Neurology

Year: 2003

Volume: 54

Issue: 2

Pages: 235-238

ISSN (print): 0364-5134

ISSN (electronic): 1531-8249

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/ana.10639

DOI: 10.1002/ana.10639

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