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Lookup NU author(s): Dr Jonathan Wallis
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BACKGROUND: TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported. STUDY DESIGN AND METHODS: This study was an observational study carried out in a single hospital. RESULTS: Eleven cases of TRALI were recognized over 12 years. In 10 cases the implicated donor unit was FFP and in 1 case uncertain. All implicated donors were parous women. In 4 cases the presumed causative antibodies were to an HLA class II antigen only. Specific anti-neutrophil antibodies, possibly causative, were detected in 1 case only. Ten of the 11 cases required mechanical ventilatory support. Five persons died as a result of the TRALI The observed incidence of TRALI caused by FFP is 1 in 7900 units transfused. CONCLUSION: TRALI is the most common serious adverse effect of blood transfusion in our hospital. Antibodies to FILA class II antigens should be looked for routinely when investigating a possible case of TRALI.
Author(s): Wallis JP, Lubenko A, Wells AW, Chapman CE
Publication type: Article
Publication status: Published
Journal: Transfusion
Year: 2003
Volume: 43
Issue: 8
Pages: 1053-1059
ISSN (print): 0041-1132
ISSN (electronic): 1537-2995
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1046/j.1537-2995.2003.00466.x
DOI: 10.1046/j.1537-2995.2003.00466.x
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