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Single hospital experience of TRALI

Lookup NU author(s): Dr Jonathan Wallis

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Abstract

BACKGROUND: TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported. STUDY DESIGN AND METHODS: This study was an observational study carried out in a single hospital. RESULTS: Eleven cases of TRALI were recognized over 12 years. In 10 cases the implicated donor unit was FFP and in 1 case uncertain. All implicated donors were parous women. In 4 cases the presumed causative antibodies were to an HLA class II antigen only. Specific anti-neutrophil antibodies, possibly causative, were detected in 1 case only. Ten of the 11 cases required mechanical ventilatory support. Five persons died as a result of the TRALI The observed incidence of TRALI caused by FFP is 1 in 7900 units transfused. CONCLUSION: TRALI is the most common serious adverse effect of blood transfusion in our hospital. Antibodies to FILA class II antigens should be looked for routinely when investigating a possible case of TRALI.


Publication metadata

Author(s): Wallis JP, Lubenko A, Wells AW, Chapman CE

Publication type: Article

Publication status: Published

Journal: Transfusion

Year: 2003

Volume: 43

Issue: 8

Pages: 1053-1059

ISSN (print): 0041-1132

ISSN (electronic): 1537-2995

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1046/j.1537-2995.2003.00466.x

DOI: 10.1046/j.1537-2995.2003.00466.x


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