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Cardiovascular malformations in infants of diabetic mothers

Lookup NU author(s): Dr Christopher Wren, Dr Gillian Hawthorne


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Objective: To compare the prevalence at live birth and the spectrum of cardiovascular malformations in infants born to diabetic mothers with pre-existing diabetes with that in infants of non-diabetic mothers. Design: Prospective study of all live births in the resident population of one health region, with recording of details of the outcome of all pregnancies of women with pre-existing diabetes and of all live born babies with cardiovascular malformations. Results: In the six years 1995-2000 there were 192618 live births in the study population. Cardiovascular malformations were confirmed in 22 of 609 (3.6%) babies with diabetic mothers and in 1417 of 192 009 (0.74%) babies with non-diabetic mothers. The odds ratio for a cardiovascular malformation with maternal diabetes was 5.0 (95% confidence interval 3.3 to 7.8). Combination of these results with previous reports and comparison with the spectrum of cardiovascular malformations in infants of non-diabetic mothers shows a greater than threefold excess of transposition of the great arteries, truncus arteriosus, and tricuspid atresia. Conclusions: Pre-existing maternal diabetes is associated with a fivefold increase in risk of cardiovascular malformations. Transposition of the great arteries, truncus arteriosus, and tricuspid atresia are overrepresented to produce a substantial excess of these malformations.

Publication metadata

Author(s): Wren C, Birrell G, Hawthorne G

Publication type: Article

Publication status: Published

Journal: Heart

Year: 2003

Volume: 89

Issue: 10

Pages: 1217-1220

ISSN (print): 1355-6037

ISSN (electronic):

Publisher: BMJ Group


DOI: 10.1136/heart.89.10.1217


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