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Lookup NU author(s): Manuel Perez-Gonzalez,
Professor Adrian ReesORCiD
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The inferior colliculus (IC) is the final point of convergence for auditory information in the brainstem. The dynamic pattern of activation of IC neurons is the information used by auditory processing in the thalamo-cortical system to localise and analyse sound sources. In the MiCRAM collaboration, we are developing computational models of IC neurons and networks based on experimental data to gain an understanding of how they activate and what information they provide to cortical processing. These models explore the physiologically distinct types of IC neurons described by Sivaramakrishnan and Oliver (J Neuroscience 21:2861-2877, 2001), and clarify how differences in IC neuronal response characteristics can reflect the channel types and densities expressed. The cells modelled include: • Sustained-regular cells, which spike periodically in response to depolarising current injection, • Onset cells, spiking once or a few times in response to depolarising current injection, • Pause-build cells, with a variable delayed response to depolarisation after hyperpolarisation, • Rebound cells, that exhibit a calcium spike with sodium spikes riding on it after the end of hyperpolarising current. This has three subtypes: o Rebound regular cells, with a regular response to depolarising current injection, o Rebound adapting cells, with an adapting response to depolarising current injection, and o Rebound transient cells, with a transient response to depolarising current. This modelling also begins to clarify why these cells show relatively depolarised resting potentials and low input resistance, and the functional roles played by T-type calcium channels and Kv3.1 and Kv4.x potassium channels in their dynamics.
Author(s): Erwin HR, Elshaw M, Perez-Gonzalez D, Rees A, Wermter S
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Unknown
Conference Name: Acoustic Communication by Animals
Year of Conference: 2008