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Early changes in thyroid-stimulating antibody activity following radioiodine therapy

Lookup NU author(s): Dr Akheel Syed


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Objective:The aim of this study was to determine whether or not the titre of thyroid-stimulating hormone receptor antibody with stimulating (TRAb-S) activity changes in patients with Graves' disease (GD) or toxic multinodular goitres (TMNG) 3 months after treatment with sodium iodide (I-131). Subjects and Methods: Serum specimens were obtained from 21 hyperthyroid patients (15 with GD and 6 with TMNG) at a median 0.5 months before and 3 months after I-131 treatment using a standard ablative dose of 555 MBq. TRAb-S activity was measured in a sensitive and specific luminescent bioassay employing the lulu cell line and expressed as a stimulation index (SI; normal less than or equal to1.5). Results: The mean TRAb-S in the GD patients was 2.72 SI (95% CI: 1.51-4.03) 0.5 months before administration of 1311 and 3.98 SI (95% CI: 1.20-6.76) 3 months after administration of I-131. The difference was not statistically significant at p < 0.8. It was not elevated in the TMNG patients before (0.57 SI; 95% CI: 0.41-0.73) and after (1.00 SI; 95% CI: 0.74-1.26) treatment either. Conclusions: Radioiodine therapy for GD or TMNG did not induce a significant change in TRAb-S activity at 3 months after treatment with I-131, probably due to effective antithyroid therapy or the timing of samples. Copyright (C) 2003 S. Karger AG, Basel.

Publication metadata

Author(s): Syed AA, Evans C, Ludgate M, Lazarus JH

Publication type: Article

Publication status: Published

Journal: Medical Principles and Practice

Year: 2003

Volume: 12

Issue: 4

Pages: 266-268

ISSN (print): 1011-7571

ISSN (electronic): 1423-0151

Publisher: S. Karger AG


DOI: 10.1159/000072296


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