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Long-term follow-up of autologous stem cell transplantation for refractory juvenile idiopathic arthritis

Lookup NU author(s): Professor Carel ten Cate, Emerita Professor Helen Foster, Dr Mario Abinun


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Since 1997, autologous stem cell transplantation (ASCT) had been applied to more than 40 children with polyarticular or systemic juvenile idiopathic arthritis (JIA). For this review, results of the follow-up are available from 25 children with systemic JIA and six with polyarticular JlA that were reported in detail from eight different pediatric European transplant centers. Before ASCT all children had progressive disease despite the use of corticosteroids, methotrexate (MTX) up to 1 mg/kg/week, cyclosporin (2.5 mg/kg/day) and/or anti-TNFalpha therapy. The clinical follow-up of these children ranges from 8 to 60 months (median 33 months).

Publication metadata

Author(s): Wulffraat NM, Brinkman D, Ferster A, Opperman J, ten Cate R, Wedderburn L, Foster H, Abinun M, Prieur AM, Horneff G, Zintl F, de Kleer I, Kuis W

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Conference on Stem Cells for Tolerance and Tissue Regeneration

Year of Conference: 2003

Pages: S61-S64

ISSN: 0268-3369

Publisher: Bone Marrow Transplantation, Nature Publishing Group


DOI: 10.1038/sj.bmt.1703946

Library holdings: Search Newcastle University Library for this item

ISBN: 14765365