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Use of functional imaging in parkinsonism and dementia

Lookup NU author(s): Professor David Burn, Professor John O'Brien


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Neuropsychiatric symptoms, including dementia, frequently coexist with parkinsonian disorders and may cause diagnostic confusion as well as management problems. Functional imaging studies include single photon emission computerised tomography (SPECT), positron emission tomography (PET), proton magnetic resonance spectroscopy, diffusion tensor imaging, and functional magnetic resonance imaging. This review addresses the utility of these techniques, from the clinician's perspective, focusing on the most common causes of parkinsonism and cognitive impairment, Parkinson's disease with dementia, dementia with Lewy bodies, and Alzheimer's disease. The potential and limitations of these techniques for accurate and early diagnosis, monitoring disease progression, and establishing the pathophysiological basis underlying key clinical features are considered. The development of new probes for SPECT and PET cameras capable of labeling protein aggregates (e.g., beta-amyloid) will offer exciting new insights into the spatial and temporal pattern of pathophysiological processes. Longitudinal studies with clinicopathological correlation represent the "gold standard" for fully evaluating functional imaging techniques. (C) 2003 Movement Disorder Society.

Publication metadata

Author(s): Burn DJ, O'Brien JT

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Workshop on Parkinsonism and Dementia

Year of Conference: 2003

Pages: S88-S95

ISSN: 0885-3185

Publisher: Movement Disorders, John Wiley & Sons


DOI: 10.1002/mds.10568

Library holdings: Search Newcastle University Library for this item

ISBN: 15318257