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Prospective follow-up study between 3 and 15 months after stroke - Improvements and decline in cognitive function among dementia-free stroke survivors > 75 years of age

Lookup NU author(s): Dr Clive Ballard, Dr Elise Rowan, Sally Stephens, Professor Raj KalariaORCiD, Professor Rose Anne Kenny


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Background and Purpose-Poststroke cognitive impairment is frequent. There are, however, few longitudinal studies examining delayed changes in poststroke cognition. Methods-As part of a longitudinal study of incident dementia after stroke, 115 older stroke survivors (>75 years of age) without dementia were evaluated at 3 and 15 months with a detailed neuropsychological evaluation ( including memory, attention, executive performance, and language). Results-we found that 9% of older stroke patients developed incident dementia, with significant deterioration in global cognition, memory, and attention. Only the severity of expressive language performance at 3 months was associated with dementia at follow-up. Conversely, 57 patients (50%) experienced some improvement in global cognition. None of the criteria for early cognitive impairment identified people at increased risk for dementia. Conclusions-Delayed dementia is frequent in older stoke patients, but current criteria for early cognitive impairment are not useful as predictors of cognitive deterioration. Improvement in cognition occurred in most patients.

Publication metadata

Author(s): Rowan E; Kalaria R; Kenny RA; Stephens S; Ballard C

Publication type: Article

Publication status: Published

Journal: Stroke

Year: 2003

Volume: 34

Issue: 10

Pages: 2440-2444

ISSN (print): 0039-2499

Publisher: Lippincott Williams & Wilkins


DOI: 10.1161/01.STR.0000089923.29724.CE


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