Toggle Main Menu Toggle Search

Open Access padlockePrints

Cytokine synergy, collagenases and cartilage collagen breakdown

Lookup NU author(s): Emeritus Professor Tim Cawston, Dr Jenny Milner, Dr Jonathan Catterall, Emeritus Professor Drew Rowan


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

Publication metadata

Author(s): Cawston TE, Milner JM, Catterall JB, Rowan AD

Editor(s): Saklatvala, J., Nagase, H., Salvesen, G.

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Symposia: Proteases and the Regulation of Biological Processes

Year of Conference: 2003

Pages: 125-133

ISSN: 0067-8694

Publisher: Portland Press

Library holdings: Search Newcastle University Library for this item

Series Editor(s): Biochemical Society Symposium

ISBN: 9781855781559