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Lookup NU author(s): Emeritus Professor Tim Cawston,
Dr Jenny Milner,
Dr Jonathan Catterall,
Emeritus Professor Drew Rowan
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We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.
Author(s): Cawston TE, Milner JM, Catterall JB, Rowan AD
Editor(s): Saklatvala, J., Nagase, H., Salvesen, G.
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Biochemical Society Symposia: Proteases and the Regulation of Biological Processes
Year of Conference: 2003
Publisher: Portland Press
Library holdings: Search Newcastle University Library for this item
Series Editor(s): Biochemical Society Symposium