Toggle Main Menu Toggle Search

Open Access padlockePrints

Subclinical aspirin sensitivity in subjects with nasal polyposis

Lookup NU author(s): Emerita Professor Janet WilsonORCiD, Emeritus Professor John Gibson


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


It is unclear whether subclinical airway responses to aspirin occur in subjects with nasal polyps and/or asthma without overt sensitivity. Sixty-three subjects without known aspirin sensitivity (13 controls, 17 nasal polyps alone, 15 nasal polyps and asthma and 18 asthma alone) inhaled increasing concentrations of nebulized lysine aspirin. Forced expiratory volume in 1 s (FEV1), symptoms and other potential markers of an airway response were measured. Four subjects (one polyps alone, one asthma alone, two with both) had a positive response to lysine aspirin predefined as symptoms plus a >10% fall in FEV1 from baseline. However, there was no evidence of a general subclinical response in any of the subject groups: mean (95% CI) change in FEV1; control 0.07 (-0.02,0.16) L, nasal polyps alone -0.05 (-0.16,0.05) L, nasal polyps with asthma -0.03 (-0.10,0.04) L, asthma alone -0.03 (-0.09,0.03) L. We concluded that in the absence of a suggestive clinical history, only a small proportion of patients with nasal polyposis are likely to be sensitive to aspirin. There is no evidence of general subclinical sensitivity to aspirin in subjects with nasal polyps and no relevant history.

Publication metadata

Author(s): Killen JWW, Wilson JA, Gibson GJ

Publication type: Article

Publication status: Published

Journal: Clinical Otolaryngology

Year: 2003

Volume: 28

Issue: 6

Pages: 539-544

ISSN (print): 1749-4478

ISSN (electronic): 1749-4486

Publisher: Wiley-Blackwell Publishing


DOI: 10.1046/j.1365-2273.2003.00772.x

PubMed id: 14616672


Altmetrics provided by Altmetric