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Exchange transfusion during extra corporeal membrane oxygenation used as a bridge to ABO-mismatch cardiac transplantation

Lookup NU author(s): Phil Botha, Dr Jonathan Wallis


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We report a case in which exchange transfusion was performed directly from the extracorporeal membrane oxygenation circuit in a child being bridged to cardiac transplantation. This allowed preparation for ABO-mismatched heart transplant in a child dependent on extracorporeal support, awaiting a suitable ABO-matched donor. Exchange transfusion or plasmapheresis in this setting would normally be performed on cardiopulmonary bypass to allow exsanguinations under hypothermia immediately pre-transplant. This allows little time for depletion of isohemagglutinins, occasionally leading to prolonged bypass times. We believe our method to be a safe alternative, allowing ample time for immunological preparation for ABO-incompatible transplant.

Publication metadata

Author(s): Botha P, Hasan A, Haynes S, Cassidy J, Roe J, Wallis J, Smith J

Publication type: Article

Publication status: Published

Journal: Annals of Thoracic Surgery

Year: 2006

Volume: 81

Issue: 3

Pages: 1105-1107

ISSN (print): 0003-4975

ISSN (electronic): 1552-6259

Publisher: Elsevier


DOI: 10.1016/j.athoracsur.2005.01.061


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