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Lookup NU author(s): Phil Botha,
Dr Jonathan Wallis
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We report a case in which exchange transfusion was performed directly from the extracorporeal membrane oxygenation circuit in a child being bridged to cardiac transplantation. This allowed preparation for ABO-mismatched heart transplant in a child dependent on extracorporeal support, awaiting a suitable ABO-matched donor. Exchange transfusion or plasmapheresis in this setting would normally be performed on cardiopulmonary bypass to allow exsanguinations under hypothermia immediately pre-transplant. This allows little time for depletion of isohemagglutinins, occasionally leading to prolonged bypass times. We believe our method to be a safe alternative, allowing ample time for immunological preparation for ABO-incompatible transplant.
Author(s): Botha P, Hasan A, Haynes S, Cassidy J, Roe J, Wallis J, Smith J
Publication type: Article
Publication status: Published
Journal: Annals of Thoracic Surgery
ISSN (print): 0003-4975
ISSN (electronic): 1552-6259
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