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Cholinergic neuronal deficits in CADASIL

Lookup NU author(s): Jessica Keverne, Dr Iryna Ziabreva, Dr Jennifer Court, Arthur Oakley, Professor Raj Kalaria

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Abstract

Background and Purpose-Previous evidence from MRI and acetylcholinesterase histochemistry suggests cholinergic fibers are affected in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Methods-As a measure of cholinergic function, we assessed choline acetyltransferase (ChAT) activities in the frontal and temporal neocortices and the immunocytochemical distribution of ChAT and p75 neurotrophin receptor (P75(NTR)) by in vitro imaging in the nucleus basalis of Meynert of CADASIL subjects. Results-ChAT activities were significantly reduced by 60% to 70% in frontal and temporal cortices of CADASIL cases, as were ChAT and P75NTR immunoreactivities in the nucleus basalis. Conclusions-Our findings suggest cholinergic neuronal impairment in CADASIL and implicate cholinomimetic therapy for subcortical vascular dementias.


Publication metadata

Author(s): Keverne JS, Low WCR, Ziabreva I, Court JA, Oakley AE, Kalaria RN

Publication type: Article

Publication status: Published

Journal: Stroke

Year: 2007

Volume: 38

Issue: 1

Pages: 188-191

ISSN (print): 0039-2499

ISSN (electronic): 1524-4628

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1161/01.STR.0000251787

DOI: 10.1161/01.STR.0000251787


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Funding

Funder referenceFunder name
G0400074Medical Research Council
G0500247Medical Research Council
G0502157Medical Research Council

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