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Synthesis and evaluation of novel chromogenic aminopeptidase substrates for microorganism detection and identification

Lookup NU author(s): Dr John Perry

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Abstract

The amides 8a-e and 10a-c were prepared as chromogenic aminopeptidase substrates. A range of microorganisms were grown in the presence of these compounds and coloured colonies were produced in several cases after addition of acetic acid-thus giving potential methods for the detection of aminopeptidase activity and for microorganism identification. (c) 2006 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): James AL, Perry JD, Rigby A, Stanforth SP

Publication type: Article

Publication status: Published

Journal: Bioorganic & Medicinal Chemistry Letters

Year: 2007

Volume: 17

Issue: 5

Pages: 1418-1421

ISSN (print): 0960-894X

ISSN (electronic): 1464-3405

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.bmcl.2006.11.088

DOI: 10.1016/j.bmcl.2006.11.088

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