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Lookup NU author(s): Dr Daniel Morris
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PURPOSE. To investigate changes of intraocular pressure on ascent to high altitude. METHODS. The Apex 2 medical research expedition provided the opportunity to measure intraocular pressure (IOP) and central corneal thickness (CCT) in 76 healthy lowlanders. They all arrived in La Paz, Bolivia (attitude, 3700 m), where they spent 4 days before being driven more than 2 hours to the Cosmic Physics Laboratory at Chacaltaya (5200 m) where they stayed for 7 days. IOP and CCT were measured with a handheld tonometer and ultrasound pachymetry on the first, third, and seventh days at 5200 m. Pre- and postexpedition CCT and postexpedition IOP readings at sea-level were also measured. RESULTS. IOP increased significantly from baseline after acute exposure to altitude before returning to baseline with time. IOP at baseline, change in IOP from baseline, and IOP at altitude did not predict symptoms of acute mountain sickness (AMS) or development of high-altitude retinopathy (HAR). CONCLUSIONS. Acute exposure to altitude caused a statistically significant but clinically insignificant increase in IOP. This finding may be partially explained by the change in CCT. IOP returned to baseline levels and possibly lower with prolonged exposure to altitude. Changes in IOP at altitude are not predictive of symptoms of acute mountain sickness (AMS) or development of high-altitude retinopathy (HAR).
Author(s): Somner JEA, Morris DS, Scott KM, MacCormick IJC, Aspinall P, Dhillon B
Publication type: Article
Publication status: Published
Journal: Investigative Ophthalmology & Visual Science
Year: 2007
Volume: 48
Issue: 4
Pages: 1622-1626
ISSN (print): 0146-0404
ISSN (electronic): 1552-5783
Publisher: Association for Research in Vision and Ophthalmology
URL: http://dx.doi.org/10.1167/iovs.06-1238
DOI: 10.1167/iovs.06-1238
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