Toggle Main Menu Toggle Search

Open Access padlockePrints

Prosthetic valve endocarditis: Importance of surgical treatment

Lookup NU author(s): Dr Stephan Schueler

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Surgical therapy of prosthetic valve endocarditis (PVE) is still associated with a high mortality of up to 80%. Further risk analysis and characterization of clinical features are important for a further improvement of surgical results. The aim of this retrospective study was a risk analysis of clinical features of the pre-, intra-, and postoperative period. Between February 1998 and December 2004, 70 patients (52 male, 18 female, age 62 +/- 11 years) were referred to our institution for surgical therapy of PVE. This cohort included 16 patients with early PVE and 54 patients with late PVE. Preoperative, intra-operative and postoperative features were evaluated with respect to their influence on the early postoperative course and the midterm follow-up. The aortic valve was affected in 41 patients (58.6%) and the mitral valve in 15 patients (21.4%). Double valve infection was recorded in 14 patients (20.0%). Staphylococci (n = 36, 51.4%), Streptoccoci (n = 9, 12.9%) and others (n = 24, 14.5%) were identified as causative agents in blood cultures. The hospital mortality rate was 20.0% (n = 14), during follow-up (mean follow up: 3.3 +/- 2.5 years), a further 11 patients (15.7%) died, resulting in an overall mortality of 35.7%. The main predictors for hospital mortality were preoperative heart failure (p = 0.01) and Staphylococci infection (p = 0.01). Predictors of overall mortality were Staphylococci infection (p = 0.01), heart failure (p = 0.02) and abscess formation (p = 0.02). Surgical therapy of prosthetic valve endocarditis is still associated with quite a high mortality during the early and midterm follow-up. Predictors of outcome particularly include preoperative risk constellations (heart failure, Staphylococci infection).


Publication metadata

Author(s): Tugtekin S, Matschke K, Daubner D, Kappert U, Schueler S, Wilbring M, Knaut M, Alexiou K

Publication type: Article

Publication status: Published

Journal: Thoracic and Cardiovascular Surgeon

Year: 2007

Volume: 55

Issue: 2

Pages: 94-98

ISSN (print): 0171-6425

ISSN (electronic): 1439-1902

Publisher: Georg Thieme Verlag

URL: http://dx.doi.org/10.1055/s-2006-924569

DOI: 10.1055/s-2006-924569


Altmetrics

Altmetrics provided by Altmetric


Share