ePrints

Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871⁺

Lookup NU author(s): Dr Alfred Jones, Professor Michael Goodfellow

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.

Publication metadata

Author(s): Graf E, Schneider K, Nicholson G, Strobele M, Jones AL, Goodfellow M, Beil W, Sussmuth RD, Fiedler HP

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2007

Volume: 60

Issue: 4

Pages: 277-284

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ja.2007.35

DOI: 10.1038/ja.2007.35

Altmetrics

Share