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Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871+

Lookup NU author(s): Dr Alfred Jones, Professor Michael Goodfellow


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Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.

Publication metadata

Author(s): Graf E, Schneider K, Nicholson G, Strobele M, Jones AL, Goodfellow M, Beil W, Sussmuth RD, Fiedler HP

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2007

Volume: 60

Issue: 4

Pages: 277-284

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group


DOI: 10.1038/ja.2007.35


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