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Change in cardiovascular risk status after dental clearance

Lookup NU author(s): Professor Janice EllisORCiD, Dr Paul Averley, Professor Philip Preshaw, Emeritus Professor Jimmy Steele CBE, Emeritus Professor Robin Seymour, Professor Mark Thomason


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There is considerable debate over the relationship between periodontal and cardiovascular disease.(1) It has been postulated that inflammatory mediators prevalent in periodontal disease may impact on atheroma formation and the thrombotic process.(2) In cross-sectional, observational studies, periodontitis is associated with elevated C-reactive protein (CRP), hyperfibrinogenaemia and moderate leukocytosis.(3-6) CRP levels have also been shown to decrease following periodontal therapy.(7) CRP is a reliable marker of the acute phase reaction to infections and/or inflammation and is a powerful predictor of future coronary events.(8-11).

Publication metadata

Author(s): Ellis JS, Averley PA, Preshaw PM, Steele JG, Seymour RA, Thomason JM

Publication type: Article

Publication status: Published

Journal: British Dental Journal

Year: 2007

Volume: 202

Issue: 9

Pages: 543-544

ISSN (print): 0007-0610

ISSN (electronic): 1476-5373

Publisher: Nature Publishing Group


DOI: 10.1038/bdj.2007.373


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