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Lookup NU author(s): Professor Janice EllisORCiD, Dr Paul Averley, Professor Philip Preshaw, Emeritus Professor Jimmy Steele CBE, Emeritus Professor Robin Seymour, Professor Mark Thomason
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There is considerable debate over the relationship between periodontal and cardiovascular disease.(1) It has been postulated that inflammatory mediators prevalent in periodontal disease may impact on atheroma formation and the thrombotic process.(2) In cross-sectional, observational studies, periodontitis is associated with elevated C-reactive protein (CRP), hyperfibrinogenaemia and moderate leukocytosis.(3-6) CRP levels have also been shown to decrease following periodontal therapy.(7) CRP is a reliable marker of the acute phase reaction to infections and/or inflammation and is a powerful predictor of future coronary events.(8-11).
Author(s): Ellis JS, Averley PA, Preshaw PM, Steele JG, Seymour RA, Thomason JM
Publication type: Article
Publication status: Published
Journal: British Dental Journal
Year: 2007
Volume: 202
Issue: 9
Pages: 543-544
ISSN (print): 0007-0610
ISSN (electronic): 1476-5373
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1038/bdj.2007.373
DOI: 10.1038/bdj.2007.373
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