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Lookup NU author(s): Professor Mushtaq Saleem,
Dr Richard WilkinsORCiD,
Dr David Mantle
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To further elucidate the possible involvement of intracellular protein catabolism in the development of insecticide resistance, we determined in vivo effect of the potent synthetic pyrethroid, beta-cyfluthrin on the activities of cytoplasmic and lysosomal proteolytic enzymes in insecticide-resistant and susceptible strain of housefly, Musca domestica. beta-Cyfluthrin at LC50 dose after 48 hour treatment decreased all cytoplasmic and lysosomal proteases in living (ranging from 15 to 87%) and dead flies (ranging from 17 to 88%) of susceptible strain except proline endopeptidase, which increased. beta-cyfluthrin also considerably inhibited all proteases of both live (ranging from 20 to 70 %) and dead flies (ranging from 53 to 77%) of resistant strain. Higher level of inhibition of all proteases of resistant strain by beta-cyfluthrin revealed efficacy of the insecticide to control resistant strain effectively, as well as possible involvement of proteases in the development of insect resistance to insecticides.
Author(s): Saleem MA, Wilkins RM, Mantle D, Shakoori AR
Publication type: Article
Publication status: Published
Journal: Pakistan Journal of Zoology
Print publication date: 01/01/2007
ISSN (print): 0030-9923
Publisher: Zoological Society of Pakistan