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Chronic excretion of a norovirus in a child with cartilage hair hypoplasia (CHH)

Lookup NU author(s): Professor Andrew Cant, Professor Andrew GenneryORCiD


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We have demonstrated the long-term excretion of a stable recombinant norovirus in a patient with cartilage hair hypoplasia (CHH), with a T cell immunodeficiency, following bone marrow transplantation (BMT). The patient excreted an ARG320/1999/US-like recombinant norovirus (rGII-3) for 156 days during a period of immune reconstitution. The child was symptomatic during the period of virus shedding. It is not known if the child acquired the recombinant strain or if recombination occurred in vivo. (C) 2003 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Gallimore CI, Lewis D, Taylor C, Cant A, Gennery A, Gray JJ

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Virology

Year: 2004

Volume: 30

Issue: 2

Pages: 196-204

ISSN (print): 1386-6532

ISSN (electronic): 1873-5967

Publisher: Elsevier BV


DOI: 10.1016/j.jcv.2003.10.007


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