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Lookup NU author(s): Tino Kurz,
Professor Thomas von Zglinicki
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Data show that specifically chelating lysosomal redox-active iron can prevent most H2O2-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage by taking part in Fenton reactions.
Author(s): Kurz T, Leake A, von Zglinicki T, Brunk UT
Editor(s): De Grey, A.D.N.
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May be Forseeable
Year of Conference: 2004
Publisher: New York Academy of Sciences
Library holdings: Search Newcastle University Library for this item
Series Title: Annals of the New York Academy of Sciences