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Topical benzydamine cream and the relief of pressure pain

Lookup NU author(s): Dr Mary Prentice


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Objective: To determine whether topical benzydamine hydrochloride 3% cream is more effective than placebo in reducing pain related to pressure areas in palliative care patients. Design: Randomized double-blind, placebo-controlled trial. Setting: Three specialist palliative care units in the north of England, with local ethical committee approval for all sites. Subjects: Hospice in-patients with pain related to pressure areas. Interventions: A single application of either benzydamine hydrochloride 3% cream or placebo cream to the painful pressure area. Main outcome measures: Pain assessed using 100 mm VAS, an 11-point numerical pain score and a five-point pain relief score. Results: There was no statistically significant difference between topical benzydamine hydrochloride 3% cream and placebo cream in reducing pain related to pressure areas in palliative care patients. Conclusions: This study does not demonstrate a statistically significant difference between the two treatments. However the study does provide reliable information with respect to the use of different pain measurement tools in late-stage palliative patients. It also provides information regarding the baseline characteristics of this group of patients which may be useful in the planning of any future similar studies.

Publication metadata

Author(s): Prentice WM, Roth LJ, Kelly P

Publication type: Article

Publication status: Published

Journal: Palliative Medicine

Year: 2004

Volume: 18

Issue: 6

Pages: 520-524

ISSN (print): 0269-2163

ISSN (electronic): 1477-030X

Publisher: Sage

URL: http://dx.doiorg/10.1191/0269216304pm926oa

DOI: 10.1191/0269216304pm926oa


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