Browse by author
Lookup NU author(s): Professor Raj KalariaORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
An in situ approach was used to identify the oxidized RNA nucleoside 8-hydroxyguanosine (8OHG) in the frontal cortex of familial Alzheimer's disease (FAD) with a mutation in presenilin-1 (PS-1) or amyloid protein precursor (AOPP) gene (n = 13, age 47-81 years). Neurons with marked 80HG immunoreaction in the cytoplasm were widely distributed in the superior/middle frontal gyros of FAD. Relative intensity measurements of neuronal 80HG immunoreactivity showed that there was a significant increase in FAD compared with controls (n = 15, age 59-81 years), while there was no difference in relative 80HG between the PS-1 and the AOPP FAD. Interestingly, a presymptomatic case carrying a PS-1 mutation showed a considerable level of relative 8OHG, and the increased levels of neuronal 80HG in FAD were more prominent in cases with a lower percentage area of Abeta42 burden. These results suggest that oxidative stress is an early event involved in the pathological cascade of FAD. (C) 2004 Elsevier Inc. All rights reserved.
Author(s): Nunomura A, Chiba S, Lippa CF, Cras P, Kalaria RN, Takeda A, Honda K, Smith MA, Perry G
Publication type: Article
Publication status: Published
Journal: Neurobiology of Disease
Year: 2004
Volume: 17
Issue: 1
Pages: 108-113
ISSN (print): 0969-9961
ISSN (electronic): 1095-953X
Publisher: Academic Press
URL: http://dx.doi.org/10.1016/j.nbd.2004.06.003
DOI: 10.1016/j.nbd.2004.06.003
Altmetrics provided by Altmetric
