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Life-style modification in peripheral arterial disease

Lookup NU author(s): Dr Jonathan Smout, Professor Gerard Stansby


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Objective. To review the published evidence supporting the use of life-style modification in peripheral arterial disease (PAD). Design. A systematic search of the medical literature zoos performed for relevant studies. Materials. The publications obtained were then searched for randomised clinical trials which reported end-points Of mortality or major cardiovascular event rates with various life-style modifications. Results. Only one randomised controlled trial was found reporting relevant end-points. Other trials were of other endpoints such as walking distance or biochemical markers. Conclusions. There is a lack of randomised controlled data proving the benefit of life-style modification in improving mortality and reducing cardiovascular events in patients with PAD. Despite this there is sufficient evidence to recommend some life-style modification as part of the overall approach to risk reduction in these patients. There is compelling evidence to support smoking cessation, increased exercise and improved diet.

Publication metadata

Author(s): Khan S, Cleanthis M, Smout J, Flather M, Stansby G

Publication type: Review

Publication status: Published

Journal: European Journal of Vascular and Endovascular Surgery

Year: 2005

Volume: 29

Issue: 1

Pages: 2-9

ISSN (print): 1078-5884

ISSN (electronic): 1532-2165


DOI: 10.1016/j.ejvs.2004.09.020